Non-Asthmatic Children Have Higher IgM Anti-Enterovirus 71 and Lower IgE Levels, but Higher IL-2 and IL-4 Levels Than Asthmatic Children

S U N D A Y 361 The Association Between Vitamin D Insufficiency and Children with Asthma Ji Tae Choung, MD, Yu-Ri Kim, Sungchul Seo, Young Yoo, MD, PhD; The Environmental Health Center for Asthma; Korea Univ. Medical Center, Seoul, Department of Biochemistry and Molecular Biology, Korea University Medical School & College, Korea, Seoul, The Enviornmental Health Center for Asthma, Korea University, Seoul, Department of Pediatrics, College of Medicine, Korea University, Seoul, South Korea. RATIONALE: Recent epidemiologic studies have shown that the lack of vitamin D levels may be associated with higher asthma prevalence. However, little clinical evaluation was performed in Korea. This study aimed to explore the association of vitamin D levels in serum with asthmatic children in Korea. METHODS: A total of 64 children (34 asthmatic children and 30 healthy children) aged 6-14 years were recruited. Serum 25-hydroxy vitamin D3 (25-OH vitamin D) levels were measured and compared between the both groups. Pulmonary function tests (PFT) as well as questionnaire survey including time of outdoor activity were performed as well. The relationship between serum 25-OH vitamin D levels and the results of PFT as well as time of outdoor activity were examined in asthmatic patients. RESULTS: Serum 25-OH vitamin D levels in asthmatic patients (16.66 4.2 ng/ml) were significantly lower than that in healthy controls (24.2 6 6.8 ng/ml) (P