Back to Search
Start Over
Sensitive square-wave voltammetric determination of tadalafil (Cialis®) in pharmaceutical samples using a cathodically pretreated boron-doped diamond electrode
- Source :
- Diamond and Related Materials. 77:153-158
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- This work presents the development of a novel voltammetric method for a sensitive, simple, fast and eco-friendly determination of tadalafil (TDL) using a cathodically pretreated boron-doped diamond electrode (CP-BDDE). Using cyclic voltammetry of TDL, this drug presented one irreversible and well resolved oxidation process at 0.905 V (vs Ag/AgCl (KCl 3.0 mol L −1 )) in Britton-Robinson buffer solution (pH 4.0). A scan rate study demonstrated that TDL transport toward CP-BDDE is diffusion controlled and one proton and one electron are involved in its electrooxidation. Employing square-wave voltammetry under optimized parameters, there was a linear dependence of peak current and TDL concentration in the range of 0.15–1.28 μmol L −1 with a detection limit of 19.5 nmol L −1 . The proposed method was successfully applied in TDL determination in pharmaceutical formulations. The results obtained with the voltammetric method were not statistically different from the comparative spectrophotometric method, at a 95% confidence level.
- Subjects :
- Detection limit
Horizontal scan rate
Materials science
Mechanical Engineering
010401 analytical chemistry
Analytical chemistry
Diamond
02 engineering and technology
General Chemistry
Square wave
Buffer solution
engineering.material
021001 nanoscience & nanotechnology
01 natural sciences
0104 chemical sciences
Electronic, Optical and Magnetic Materials
chemistry.chemical_compound
chemistry
Electrode
Materials Chemistry
engineering
Electrical and Electronic Engineering
Cyclic voltammetry
0210 nano-technology
Voltammetry
Subjects
Details
- ISSN :
- 09259635
- Volume :
- 77
- Database :
- OpenAIRE
- Journal :
- Diamond and Related Materials
- Accession number :
- edsair.doi...........34ee51a5dda848586f6247f28411c4af
- Full Text :
- https://doi.org/10.1016/j.diamond.2017.07.001