Striking dichotomy in outcome ofMYCN-amplified neuroblastoma in the contemporary era

BACKGROUND The authors exploited a large database to investigate the outcomes of patients with high-risk neuroblastoma in the contemporary era. METHODS All patients with high-risk neuroblastoma aged 18 months with MYCN-nonamplified [MYCN(−)] stage 4 disease. RESULTS A complete response/very good partial response (CR/VGPR) to induction was correlated with significantly superior event-free survival (EFS) (P