Conjugate-elimination on unsaturated acetals: A one-step route to functionalized 1,3-dienes

Authors :: Yann Le Gallic
Jacques Maddaluno
Odile Gaonac'h
Lucette Duhamel
Source :: Tetrahedron Letters. 36:8591-8594
Publication Year :: 1995
Publisher :: Elsevier BV, 1995.
Abstract: γ-Functionalized α,β-unsaturated dimethyl acelals undergo a methanol δ-elimination upon basic treatment, leading to 1,4-disubstituted 1,3-dienes in good yields and, in several cases, with high stereocontrol of the newly formed double bonds.

Subjects :: chemistry.chemical_classification
chemistry.chemical_compound
Double bond
Chemistry
Stereochemistry
Organic Chemistry
Drug Discovery
One-Step
Methanol
Biochemistry
Combinatorial chemistry
Conjugate

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