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Involvement of the catecholaminergic system in the inhibitory effect of brain histamine on growth hormone secretion
- Source :
- Agents and Actions. 38:C272-C274
- Publication Year :
- 1993
- Publisher :
- Springer Science and Business Media LLC, 1993.
-
Abstract
- The effects of intracerebroventricular (icv) injection of histamine (HA, 0.4 μmol/rat) or of the inhibitor of HA synthesisα-fluoromethylhistidine (αFMH, 100 mg/kg, intracarotid (ia)) on growth hormone (GH) secretion induced by GH-releasing hormone (hGHRH1–40, 2 μg/kg, ia) in freely moving rats were examined. HA significantly inhibited GH release induced by GHRH whereas pretreatment (3 h before) with αFMH enhanced the GH response to GHRH.
- Subjects :
- Pharmacology
Catecholaminergic
Allergy
medicine.medical_specialty
Immunology
Toxicology
medicine.disease
Growth hormone secretion
chemistry.chemical_compound
Endocrinology
chemistry
Dopamine
Internal medicine
Catecholamine
medicine
Pharmacology (medical)
Secretion
hormones, hormone substitutes, and hormone antagonists
Histamine
medicine.drug
Hormone
Subjects
Details
- ISSN :
- 1420908X and 00654299
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Agents and Actions
- Accession number :
- edsair.doi...........349dd17a4bc2fd6d1d78a0f1727275a7
- Full Text :
- https://doi.org/10.1007/bf01996483