FORMULATION OF DEXIBUPROFEN SOLID LIPID NANO PARTICLES AND ITS EVALUATION BY IN VITRO DISSOLUTION STUDY

D exibuprofen is a poorly water soluble nonsteroidal anti - inflammatory drug, prescribed for moderate to severe p ain and inflammation. It is the active dextrorotatory enantiomer of ibuprofen and has better anti - in flammatory effect . Hence present study was carried out to enhance dissolution properties of dexibuprofen through the preparation of solid lipid nano particl es (SLNPs) using stearic acid as lipid, lutrol F - 68 (Poloxamer) as surfactant and tween - 80 as stabilizer by hot homogenization method. Six formulations were prepared in different ratios and were designated as DNP1 to DNP6 . USP type II rotating paddle disso lution studies in 900 ml distilled water at 50 rpm to a temperature of 37°C ± 0.5°C were performed for evaluation of solid lipid nano particles. UV s pectrophotometric method was selected for assay as well as in - vitro dissolution studies at λ max 222 nm. The drug release profil e followed zero order and first order kinetics. In - vitro studies showed that solubility and dissolution rate of dexibuprofen were significantly improved by SLN formulation than the d rug alone . This result may trigger mor e research in the intension of exploiting this feature to develop a novel drug delivery system for dexibuprofen with enhanced bioavailability.