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Benzimidazoles and related heterocycles 10. A novel acid-catalyzed rearrangement in the system 3-(α-aminobenzyl)quinoxalin-2(1H)-one-ethyl acetoacetate as a simple and efficient method for synthesizing 2-(pyrrol-3-yl)benzimidazoles
- Source :
- Russian Chemical Bulletin. 60:368-372
- Publication Year :
- 2011
- Publisher :
- Springer Science and Business Media LLC, 2011.
-
Abstract
- A reaction of 3-(α-aminobenzyl)quinoxalin-2(1H)-one with ethyl acetoacetate in boiling acetic acid is accompanied by contraction of the pyrazine ring. A rearrangement involving the fragment C(2)-C(3)-C(NH2)Ph of the quinoxaline system and the fragment C(2)-C(3) of ethyl acetoacetate yields 2-(4-ethoxycarbonyl-5-methyl-2-phenylpyrrol-3-yl)benzimidazole. Possible pathways of this reaction are considered.
Details
- ISSN :
- 15739171 and 10665285
- Volume :
- 60
- Database :
- OpenAIRE
- Journal :
- Russian Chemical Bulletin
- Accession number :
- edsair.doi...........3487fb3a278847823ccfd3f91af41c89