Electrospun hemocompatible PU/gelatin-heparin nanofibrous bilayer scaffolds as potential artificial blood vessels

Cardiovascular diseases are one of the most frequent causes of death all over the world. Particularly in recent years, coronary heart diseases showed a significantly increasing trend. Nowadays artificial blood vessels have become an important implant for the treatment of a serious stenosis or occlusion of blood vessels in clinic. Synthetic polymers, such as polytetrafluoroethylene and polyurethanes, have been successfully used as large diameter artificial blood vessels, but long term patency of small artificial diameter vessels (