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The Systemic Inflammation Marker NLR as a Prognostic Factor in Complicated Colorectal Cancer
- Source :
- Journal of Biomedical Research & Environmental Sciences. 4:141-149
- Publication Year :
- 2023
- Publisher :
- SciRes Literature LLC, 2023.
-
Abstract
- Many recent scores based on the inflammatory response, such as Neutrophil Lymphocyte Ratio (NLR), Platelet Lymphocyte Ratio (PLR), Lymphocyte Monocyte Ratio (LMR) have been demonstrated to have a prognostic value in cancer patients. The ratio between neutrophils and lymphocytes is a very useful tool, most studies admitting its role as a prognostic marker in cancer. We made a retrospective study on 391 patients hospitalized and operated in emergency for complicated colorectal cancer in the Surgery II clinic of the "St. Ap. Andrei" from Galati, Romania, between 2008-2017. We demonstrated that the increased preoperative value of NLR was a negative prognostic factor for long-term survival in patients with complicated colorectal cancer (HR = 7.581, 95% CI = (6.358,9.039) (p = 0.000000)). The cut-off point is > 2.61, with sensitivity of 73.61 and specificity of 100.00. The mean survival time in patients with NLR < = 2.61 was 39,676, 95% CI = (37,189, 42,163) and in those with NLR > 2.61 it was 12,504, 95% CI = (11,747, 13,261), the difference between the survival time of patients with values above the cutoff and below the cutoff being statistically significant (p = 0.000000, Log-Rank).
- Subjects :
- Ocean Engineering
Subjects
Details
- ISSN :
- 27662276
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of Biomedical Research & Environmental Sciences
- Accession number :
- edsair.doi...........342e4901cf20254a2f60259ed7001803