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An efficient one-pot synthesis of tetra-substituted pyrroles
- Source :
- Tetrahedron. 67:5415-5420
- Publication Year :
- 2011
- Publisher :
- Elsevier BV, 2011.
-
Abstract
- The three-component reaction of primary amines, dialkyl acetylenedicarboxylates and β-nitrostyrene derivatives in the presence of Iron(III) chloride afforded 1,2,3,4-tetra-substituted pyrroles in high yields. These reactions could precede via domino Michael addition/cyclization process.
- Subjects :
- chemistry.chemical_classification
biology
Chemistry
Organic Chemistry
One-pot synthesis
Nitro compound
biology.organism_classification
Biochemistry
Chloride
Medicinal chemistry
Domino
chemistry.chemical_compound
One pot reaction
Drug Discovery
Michael reaction
medicine
Tetra
Iron(III) chloride
medicine.drug
Subjects
Details
- ISSN :
- 00404020
- Volume :
- 67
- Database :
- OpenAIRE
- Journal :
- Tetrahedron
- Accession number :
- edsair.doi...........34207c43ea7a3802ebda87f593dce06d
- Full Text :
- https://doi.org/10.1016/j.tet.2011.05.076