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Increased frequency of CD4+CD25highCD127lowT cells early after lung transplant is associated with improved graft survival – a retrospective study
- Source :
- Transplant International. 33:503-516
- Publication Year :
- 2020
- Publisher :
- Frontiers Media SA, 2020.
-
Abstract
- In this retrospective study, we analyzed the presence of any association of three CD4+ CD25high regulatory T-cell subpopulations at 3 weeks after lung transplantation with the later incidence of chronic lung allograft dysfunction and graft survival. Among lung-transplanted patients between January 2009 and April 2018, only patients with sufficient T-cell measurements at 3 weeks after transplantation were included into the study. Putative regulatory T cells were defined as CD4+ CD25high T cells, detected in peripheral blood and further analyzed for CD127low , FoxP3+ , and CD152+ using fluorescence-activated cell sorting (FACS) analysis. Associations of regulatory T cells with chronic lung allograft dysfunction (CLAD) and graft survival were evaluated using Cox analysis. During the study period, 724 (71%) patients were included into the study. Freedom from chronic lung allograft dysfunction (CLAD) and graft survival amounted to 66% and 68% at 5 years. At the multivariable analysis, increasing frequencies of CD127low were associated with better freedom from CLAD (hazard ratio for each 1% increase of %CD127low , HR = 0.989, 95% CI = 0.981-0.996, P = 0.003) and better graft survival (HR = 0.991, 95% CI = 0.984-0.999, P = 0.026). A higher frequency of CD127low regulatory T cells in peripheral blood early after lung transplantation estimated a protective effect against chronic lung allograft dysfunction, mortality, and re-transplantation.
- Subjects :
- Transplantation
medicine.medical_specialty
Lung
business.industry
Regulatory T cell
Incidence (epidemiology)
medicine.medical_treatment
Hazard ratio
FOXP3
Retrospective cohort study
Gastroenterology
surgical procedures, operative
medicine.anatomical_structure
Internal medicine
medicine
Lung transplantation
business
Subjects
Details
- ISSN :
- 14322277 and 09340874
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Transplant International
- Accession number :
- edsair.doi...........33d5c95f08a19b946689fb5f016c19d3