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[99mTc]Tc-iPSMA SPECT brain imaging as a potential specific diagnosis of metastatic brain tumors and high-grade gliomas
- Source :
- Nuclear Medicine and Biology. :1-8
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Background PSMA (prostate-specific membrane antigen) protein is heavily expressed in the proliferating microvasculature of high-grade gliomas (HGG) and brain metastases (BM). This research aimed to assess [99mTc]Tc-iPSMA SPECT brain imaging as a potential specific diagnosis of HGG and BM by PSMA-targeting in their proliferating vasculature. Methods Forty-one patients, with suspected brain tumors, as detected by enhanced MRI scanning, were enrolled to undergo preoperative [99mTc]Tc-iPSMA SPECT brain imaging. Semiquantitative image analyses, to evaluate the maximum target-to-background ratio (TBRmax), were performed. All diagnoses were histopathologically confirmed. PSMA expression was evaluated by immunohistochemistry (IHC) in 11 brain tumor tissues. TBRmax values were correlated with IHC results and tumor WHO grade (HGG vs LGG). Results [99mTc]Tc-iPSMA images showed increased uptake in BM, HGG, and recurrent gliomas (TBRmax of 25.1 ± 7.1, 18.5 ± 9.0, 15.0 ± 9.9, respectively), and was negative in treatment-naive patients with LGG and reactive gliosis. PSMA was highly expressed in the vascular endothelium of grade IV gliomas and BM, while its expression was extremely low in LGG and completely absent in gliosis. By using 2.8 as a threshold value for TBRmax, the specificity, sensitivity, PPV, NPV and accuracy were 100%, 94%, 100%, 77% and 95%, respectively. Conclusions The results of this pilot study show that [99mTc]Tc-iPSMA SPECT brain imaging is a specific and potentially useful neuroimaging tool for assessing tumoral neovasculature formation in gliomas and brain metastases.
- Subjects :
- Cancer Research
Pathology
medicine.medical_specialty
Reactive gliosis
business.industry
Brain tumor
SPECT Brain
medicine.disease
030218 nuclear medicine & medical imaging
Vascular endothelium
03 medical and health sciences
0302 clinical medicine
Gliosis
Neuroimaging
030220 oncology & carcinogenesis
Glioma
medicine
Molecular Medicine
Immunohistochemistry
Radiology, Nuclear Medicine and imaging
medicine.symptom
business
Subjects
Details
- ISSN :
- 09698051
- Database :
- OpenAIRE
- Journal :
- Nuclear Medicine and Biology
- Accession number :
- edsair.doi...........335c25e088cde048172e1a1d81933de6