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Simple and Dendritic Cyclam Derivatives. Photophysical Properties, Effect of Protonation and Zn2+ Coordination, Preliminary Screening as Inhibitors of Tumour Cell Growth
- Source :
- Supramolecular Chemistry. 16:541-548
- Publication Year :
- 2004
- Publisher :
- Informa UK Limited, 2004.
-
Abstract
- We have synthesized two novel dendrimers (BG1 and BG2) consisting of a 1,4,8,11-tetraazacyclotetradecane (cyclam, 1) core with appended four dimethoxybenzene and eight benzyl units (BG1) and twelve dimethoxybenzene and sixteen benzyl units (BG2). The absorption and luminescence spectra of these compounds and the changes taking place upon protonation and Zn2+ coordination of their cyclam core have been investigated in acetonitrile-dichloromethane 1:1 v/v solution. For comparison purposes, the absorption and luminescence spectra of 1,4,8,11-tetrabenzyl-cyclam (2), and dendrons BD1 and BD2, model compounds of the branches of BG1 and BG2 respectively, have also been studied. BD1, BD2, BG1, and BG2 exhibit the absorption and emission spectra of their 1,3-dimethoxybenzene unit, but in the two dendrimers the emission intensity is quenched by the cyclam amine groups and increases upon protonation and metal coordination. In order to test if these cyclam derivatives have an antitumour effect, we have studied their ...
Details
- ISSN :
- 10290478 and 10610278
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Supramolecular Chemistry
- Accession number :
- edsair.doi...........33305332b2eb02490eaef93e0410cecd