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The relationship between primary prescription opioid and buprenorphine-naloxone induction outcomes in a prescription opioid dependent sample
- Source :
- The American Journal on Addictions. 23:343-348
- Publication Year :
- 2013
- Publisher :
- Wiley, 2013.
-
Abstract
- Background and objectives This analysis aims to: (1) compare induction experiences among participants who self-reported using one of the four most commonly reported POs, and (2) examine factors associated with difficult bup-nx induction. Our hypothesis, based on previous research and current guidelines, is that those on longer-acting opioids will have experienced more difficult inductions. Methods The Prescription Opioid Addiction Treatment Study (POATS) was a multi-site, randomized clinical trial, using a two-phase adaptive treatment research design. This analysis examines bup-nx induction of participants who self-reported primary PO use of methadone, ER-oxycodone, IR-oxycodone, and hydrocodone (n = 569). Analyses examined characteristics associated with difficult induction, defined as increased withdrawal symptoms measured by the Clinical Opiate Withdrawal Scale (COWS) after the first bup-nx dose with higher scores denoting greater withdrawal symptoms/severity. Results Contrary to our hypothesis, difficult induction experiences did not differ by primary PO type. Those who experienced a post-induction increase in COWS score had lower pre-dose COWS scores compared to those who did not experience a post-induction increase in COWS score (10.09 vs. 12.77, t(624) = −13.56, p
- Subjects :
- medicine.medical_specialty
business.industry
Medicine (miscellaneous)
Treatment research
law.invention
Psychiatry and Mental health
Clinical Psychology
Randomized controlled trial
Hydrocodone
Prescription opioid
law
Anesthesia
Internal medicine
Buprenorphine/naloxone
medicine
business
Depression (differential diagnoses)
medicine.drug
Buprenorphine
Methadone
Subjects
Details
- ISSN :
- 10550496
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- The American Journal on Addictions
- Accession number :
- edsair.doi...........3317949bc3a6e86ab6755696cc3a9d12