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The Enterokine Fibroblast Growth Factor 15/19 in Bile Acid Metabolism
- Source :
- Bile Acids and Their Receptors ISBN: 9783030220044
- Publication Year :
- 2019
- Publisher :
- Springer International Publishing, 2019.
-
Abstract
- The endocrine fibroblast growth factors (FGFs), FGF19, FGF21, and FGF23, play a key role in whole-body homeostasis. In particular, FGF19 is a postprandial hormone regulating glucose homeostasis, glycogen and protein synthesis, and primary bile acid (BA) metabolism. In the ileum, BA-dependent farnesoid X receptor (FXR) activation induces the production of FGF19, which reaches the liver through the portal system where it represses the expression of CYP7A1, the rate-limiting enzyme of hepatic de novo BAs synthesis. Dysregulation of BA levels associated with alteration in FGF19 level has been depicted in different pathological conditions of the gut-liver axis. Furthermore, FGF19 exploits strong anti-cholestatic and anti-fibrotic activities in the liver. However, native FGF19 seems to retain peculiar hepatic pro-tumorigenic actions. Recently engineered FGF19 analogues have been recently synthetized, with fully retained BA regulatory activity but without intrinsic pro-tumoral action, thus opening bona fide novel pharmacological strategy for the treatment of gut-liver axis diseases.
- Subjects :
- 0301 basic medicine
FGF21
Bile acid
Glycogen
medicine.drug_class
FGF19
Cholesterol 7 alpha-hydroxylase
Fibroblast growth factor
Cell biology
03 medical and health sciences
chemistry.chemical_compound
030104 developmental biology
0302 clinical medicine
chemistry
030220 oncology & carcinogenesis
medicine
Glucose homeostasis
Farnesoid X receptor
Subjects
Details
- ISBN :
- 978-3-030-22004-4
- ISBNs :
- 9783030220044
- Database :
- OpenAIRE
- Journal :
- Bile Acids and Their Receptors ISBN: 9783030220044
- Accession number :
- edsair.doi...........32f0b2eaa70a43bcec73080198dc548e