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A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia
- Source :
- Nature Medicine. 20:1130-1137
- Publication Year :
- 2014
- Publisher :
- Springer Science and Business Media LLC, 2014.
-
Abstract
- A long-range MYC enhancer is duplicated in human T-ALL and is required for T cell development and NOTCH1-induced leukemogenesis.
- Subjects :
- 0303 health sciences
Lymphoblastic Leukemia
T cell
General Medicine
Biology
Jurkat cells
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
Transformation (genetics)
0302 clinical medicine
medicine.anatomical_structure
hemic and lymphatic diseases
030220 oncology & carcinogenesis
Cancer genetics
embryonic structures
Gene duplication
cardiovascular system
Cancer research
medicine
sense organs
Lymphopoiesis
biological phenomena, cell phenomena, and immunity
Enhancer
030304 developmental biology
Subjects
Details
- ISSN :
- 1546170X and 10788956
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Nature Medicine
- Accession number :
- edsair.doi...........32d35276f3507853b755c8d572fa2ca2
- Full Text :
- https://doi.org/10.1038/nm.3665