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Convenient synthesis of chiral H4-BINOL via direct hydrogenation of BINOL
- Source :
- Chinese Chemical Letters. 21:1277-1280
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- A simple, highly effective hydrogenation of chiral BINOL to provide H4-BINOL in multigram scale with good yield (up to 78% yield) was developed. A series of heterogeneous catalysts was tested in the hydrogenation; the best result was obtained with 5% Pd/C in EtOH under the H2 pressure of 50 bar for 2 h. This method is a more useful method for practical synthesis of optically pure H4-BINOL than other available methods.
Details
- ISSN :
- 10018417
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Chinese Chemical Letters
- Accession number :
- edsair.doi...........32ce735719d7ec658c597a7d0392a5fd