Synthesis and application of cobalt and vanadium complexes for quantitative estimation of anticancer drug, Mesna

Mesna is an organosulfur compound used as an adjuvant in cancer chemotherapy and is available in injection formulation in commercial pharmaceutical market. Analytical method for quantitative estimation of Mesna by synthesis of its Cobalt (II) and Vanadium (V) complexes has been described in this research paper. Mesna form red brown colored 1:2 complex with Cobalt (II) with absorbance maximum at 488.5 nm, Beer’s law range of 0.65x102µg/ml to 10.5x102 µg/ml at neutral pH and 55 °C temperature with stability constant 3.045.With Vanadium(V) Mesna forms orange coloured 1:1 complex with absorbance maximum 405 nm, Beer’s law range 0.6 µg/ml to 3.6 µg/ml at acidic pH and 35 °C temperature with stability constant 4.343.