Square-Wave Voltammetry as Analytical Tool for Real-Time Study of Controlled Naproxen Releasing from Cellulose Derivative Materials

This work reports the successful use of square-wave voltammetry (SWV) to directly assess the controlled releasing profile of naproxen from lab-made cellulose derivative materials (membranes and microparticles) in phosphate buffer (pH 7.4) at 36 °C. Particular advantage of SWV refers to the direct real-time monitoring of released drug from cellulose derivative microparticles, which cannot be easily assessed by UV-spectrophotometry. Moreover, SWV was able to detect modifications in the naproxen releasing profile due to morphology and processing of membranes and microparticles. The possible miniaturization and versatility of SWV suggest the promising application on the study of several drug delivery systems, including in vivo studies.