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Fabrication and Characterization of Thiolated Chitosan Microneedle Patch for Transdermal Delivery of Tacrolimus
- Source :
- AAPS PharmSciTech. 21
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Microneedle patch is a prominent strategy with minimal invasion and painless application to improve skin penetration of drug molecules. Herein, we report microneedle patch (MNP) as an alternative to the oral route for the systemic delivery of tacrolimus (TM), an immunosuppressant drug. Thiolated chitosan (TCS) based microneedle patch was fabricated and characterized in vitro and in vivo for its mechanical strength, skin penetration, drug release, and skin irritation. The MNP having 225 needles with 575 μm showed good mechanical properties in terms of tensile strength and percentage elongation. The skin penetration showed 84% penetration with no breakage. Histology of the mice skin after insertion showed the penetration of needles into the dermis. In vitro release and ex vivo permeation studies through Franz diffusion cell showed the sustained release (82.5%) of TM from the MNP with significantly higher (p
- Subjects :
- Pharmaceutical Science
02 engineering and technology
Aquatic Science
030226 pharmacology & pharmacy
Chitosan
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Dermis
In vivo
Drug Discovery
medicine
Ecology, Evolution, Behavior and Systematics
Transdermal
integumentary system
Ecology
General Medicine
Penetration (firestop)
Permeation
021001 nanoscience & nanotechnology
Bioavailability
medicine.anatomical_structure
chemistry
0210 nano-technology
Agronomy and Crop Science
Ex vivo
Biomedical engineering
Subjects
Details
- ISSN :
- 15309932
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- AAPS PharmSciTech
- Accession number :
- edsair.doi...........32893ad5916b4c2a8eb76be4b2ba7a9e