Effect of injectable trace minerals (zinc, manganese, selenium, and copper) on the humoral and cell-mediated immune responses to vaccine antigens following administration of a modified-live viral vaccine in dairy calves

The benefits of administering injectable trace minerals (ITM; Zn, Mn, Cu, and Se) on animal health and performance have been previously assessed in dairy and beef cattle. Previous studies demonstrated that ITM improved humoral immune response to bovine herpesvirus l(BHV-l) following administration of a modified live virus (MLV) vaccine in cattle. The objective of this study was to evaluate the effect of an ITM supplement containing zinc, manganese, selenium, and copper on the humoral and cell mediated immune (CMI) responses to individual vaccine antigens in dairy calves receiving a MLV vaccine containing bovine viral diarrhea virus (BVDV), BHV1, parainfluenza virus 3 (PI3V), and bovine respiratory syncytial virus (BRSV).
American Association of Bovine Practitioners Proceedings of the Annual Conference, 2015