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CD34—Structure, Functions and Relationship with Cancer Stem Cells

Authors :
Petru Radu
Mihai Zurzu
Vlad Paic
Mircea Bratucu
Dragos Garofil
Anca Tigora
Valentin Georgescu
Virgiliu Prunoiu
Costin Pasnicu
Florian Popa
Petra Surlin
Valeriu Surlin
Victor Strambu
Source :
Medicina. 59:938
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

The CD34 protein was identified almost four decades ago as a biomarker for hematopoietic stem cell progenitors. CD34 expression of these stem cells has been exploited for therapeutic purposes in various hematological disorders. In the last few decades, studies have revealed the presence of CD34 expression on other types of cells with non-hematopoietic origins, such as interstitial cells, endothelial cells, fibrocytes, and muscle satellite cells. Furthermore, CD34 expression may also be found on a variety of cancer stem cells. Nowadays, the molecular functions of this protein have been involved in a variety of cellular functions, such as enhancing proliferation and blocking cell differentiation, enhanced lymphocyte adhesion, and cell morphogenesis. Although a complete understanding of this transmembrane protein, including its developmental origins, its stem cell connections, and other functions, is yet to be achieved. In this paper, we aimed to carry out a systematic analysis of the structure, functions, and relationship with cancer stem cells of CD34 based on the literature overview.

Subjects

Subjects :
General Medicine

Details

ISSN :
16489144
Volume :
59
Database :
OpenAIRE
Journal :
Medicina
Accession number :
edsair.doi...........320fe6b213cb453b8902781b99f9e126
Full Text :
https://doi.org/10.3390/medicina59050938