ChemInform Abstract: An Asymmetric Synthesis of Fully Functionalized B Ring System of Taxol

Authors :: Kouichi Uoto
Nobuaki Mori
Isamu Shiina
Tomomi Kosugi
Teruaki Mukaiyama
Source :: ChemInform. 26
Publication Year :: 2010
Publisher :: Wiley, 2010.
Abstract: Optically active 7-t-butyldimethylsiloxy-4,8-dibenzyloxy-6,6-dimethyl-5-p-methoxybenzyloxy-2-cycloocten-1-one (1) was synthesized from 3,7-dibenzyloxy-4,8-di-t-butyldimethylsiloxy-5,5-dimethyl-6-p-methoxybenzyloxy-2-octanone (2) by way of intramolecular Reformatsky-type reaction using SmI2.

Subjects :: Chemistry
Stereochemistry
Intramolecular force
Enantioselective synthesis
General Medicine
Optically active
Ring (chemistry)

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