Implant-related Metal Hypersensitivity—A Cause for Concern: A Report of Two Cases and Literature Review

The evolution of orthopedic implants has witnessed a great evolution and allowed insights into the various metals and alloys compatible with the human body. However, some recent reports have raised concerns regarding hypersensitivity to several metals used in orthopedic implants. These cases are mostly documented in the field of arthroplasty. Metal ion release following hip or knee arthroplasty is a known phenomenon and associated immune reactions to these metal ions have been implicated in the causation of these hypersensitivity reactions. These reactions frequently lead to poor outcome following these implant surgeries. We here present two rare cases of metal induced hypersensitivity reactions following orthopedic surgeries. We have also reviewed the literature in this context to look into the various causes of metal reactions, types of implant involved in hypersensitivity, methods of testing and management options in these cases. How to cite this article Kanojia R, Kumar V, Garg B, Dhillon MS. Implant-related Metal Hypersensitivity—A Cause for Concern: A Report of Two Cases and Literature Review. J Postgrad Med Edu Res 2014;48(1):37-39.