Back to Search
Start Over
Optimization of 89Zr PET Imaging for Improved Multisite Quantification and Lesion Detection Using an Anthropomorphic Phantom
- Source :
- Journal of Nuclear Medicine Technology. 48:54-57
- Publication Year :
- 2019
- Publisher :
- Society of Nuclear Medicine, 2019.
-
Abstract
- Objective: To harmonize multicenter 89Zr PET imaging for oncology trials and to evaluate lesion detection. Methods: Seven PET scanners were evaluated using a custom chest oncology phantom with nine spherical lesions, 7-20 mm in diameter. A 4:1 lesion to background ratio simulating a patient dose of 92.5 MBq. Various image reconstructions were evaluated. Images were assessed for lesion detection and recovery coefficients (RC) and background signal variance were measured. Results: Two scanners failed to meet the quality control criteria. Optimal reconstruction algorithms enabling adequate lesion detection and reliable quantification across the other five scanners were determined without compromising the data quality. On average, 95% of the 10 mm lesions were detected and the 7 mm lesion was visualized in only one scanner. The background variance range was 8.6 to 16%. Conclusion: We established multicenter harmonization procedures for 89Zr PET imaging in oncology, optimizing small lesion (≥10 mm) detectability and accurate quantification.
- Subjects :
- Scanner
Radiological and Ultrasound Technology
Lesion detection
business.industry
General Medicine
Pet imaging
Imaging phantom
030218 nuclear medicine & medical imaging
Lesion
03 medical and health sciences
0302 clinical medicine
Pet scanner
Small Lesion
Medicine
Radiology, Nuclear Medicine and imaging
Anthropomorphic phantom
medicine.symptom
business
Nuclear medicine
Subjects
Details
- ISSN :
- 15355675 and 00914916
- Volume :
- 48
- Database :
- OpenAIRE
- Journal :
- Journal of Nuclear Medicine Technology
- Accession number :
- edsair.doi...........3111bebc0145ae379eeb445f51884631