e0524 Intensive cholesterol lowering with simvastatin improves the outcomes of percutaneous coronary intervention in patients with acute coronary syndrome

Objective To evaluate the immediate protective effects of intensive statin pretreatment on myocardial perfusion and myocardial ischaemic injury during PCI. Methods A total of 228 acute coronary syndrome (ACS) patients were randomly divided into standard statin group (SSG, n=115) and intensive statin group (ISG, n=113). Patients in SSG received 20 mg simvastatin and patients in ISG received 80 mg simvastatin for 7 days before PCI. TIMI grade flow (TGF), corrected TIMI frame count (CTFC) and TIMI myocardial perfusion grade (TMPG) of the intervened vessel were recorded before and after stent deployment. Plasma level of CK-MB and cTnI were measured before and 24 h after the procedure. Results The TFG after stent deployment was significantly improved with less TIMI 0–1 patients and more TIMI 3 blood flow in ISG than in SSG (all p Conclusion Intensive statin pretreatment for 7 days before PCI can further improve myocardial blood perfusion, protect myocardium from ischaemic injury.