Genetic polymorphisms of the multidrug resistance-associated protein 2 gene (ABCC2) and Irinotecan toxicity

Authors :: Masahiko Ando
Kaoru Shimokata
Yoshinori Hasegawa
M. Usui
K. Takahashi
Chiyoe Kitagawa
Y. Sekido
Yuichi Ando
Source :: Journal of Clinical Oncology. 22:2009-2009
Publication Year :: 2004
Publisher :: American Society of Clinical Oncology (ASCO), 2004.
Abstract: 2009 Background: Irinotecan unexpectedly causes severe, occasionally fatal, toxicity of leukopenia or diarrhea. Irinotecan is metabolized by carboxylesterase to form an active SN-38, which is furth...

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