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Vinpocetine inhibits the proliferation and induces apoptosis in human colon cancer cells
- Source :
- International Journal of Oral Biology. 46:7-14
- Publication Year :
- 2021
- Publisher :
- Korean Academy of Oral Biology, 2021.
-
Abstract
- Vinpocetine induces anti-inflammatory effects in various inflammatory diseases via the inhibition of phosphodiesterase type-1-independent nuclear factor-κB signaling pathway and the release of inflammatory cytokines. In this study, we investigated the effect of vinpocetine on the proliferation of colon cancer cells and its underlying molecular mechanisms. Our data showed that vinpocetine inhibits the viability and proliferation of colon cancer cells. Vinpocetine treatment induced cell death in HCT116 cells, which the percentages of sub-G1 phase were significantly increased, and the apoptosis-related genes were regulated after HCT116 cells were treated with vinpocetine. In sum, our findings indicated that vinpocetine could be a therapeutically useful candidate in the treatment of colon cancer.
- Subjects :
- 0301 basic medicine
Programmed cell death
Chemistry
Colorectal cancer
Phosphodiesterase
030206 dentistry
medicine.disease
digestive system diseases
Proinflammatory cytokine
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Vinpocetine
Apoptosis
medicine
Cancer research
Signal transduction
Gene
medicine.drug
Subjects
Details
- ISSN :
- 22876618 and 12267155
- Volume :
- 46
- Database :
- OpenAIRE
- Journal :
- International Journal of Oral Biology
- Accession number :
- edsair.doi...........304a00d2cabdaec169a9fa808f4aab98