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Oral ivermectin to treat scabies: a comparison of two different regimens
- Source :
- Clinical and Experimental Dermatology. 48:232-234
- Publication Year :
- 2022
- Publisher :
- Oxford University Press (OUP), 2022.
-
Abstract
- As Sarcoptes scabiei is becoming less sensitive to permethrin, clinicians have started to prescribe oral ivermectin (OI) as a first-line treatment. Guidelines suggest OI 200 µg kg–1 as two doses, 1 week apart. However, the black box of the ivermectin registered in Italy recommends a single dose. To compare these two regimens, we collected 71 cases of scabies and treated them according to this protocol [single-dose group (SDG)]. This population was compared to 68 patients who received two doses 1 week apart [double-dose group (DDG)]. Clearance of the disease was achieved in 98% of DDG patients. In the SDG, treatment was successful in only 58% of patients. This study confirms that the absence of a second intake of OI is one of the main predictors of treatment failure (P < 0.001), which may also increase the likelihood of emerging resistance in S. scabiei.
- Subjects :
- Dermatology
Subjects
Details
- ISSN :
- 13652230 and 03076938
- Volume :
- 48
- Database :
- OpenAIRE
- Journal :
- Clinical and Experimental Dermatology
- Accession number :
- edsair.doi...........301f7ad97c641f32ee71dc0fd8d836fa