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The Development of Corneal Opacity, Increased Hydration and Increased Thickness in Isolated Porcine Corneas in Response to Timolol Maleate Solutions Containing Various Preservatives
The Development of Corneal Opacity, Increased Hydration and Increased Thickness in Isolated Porcine Corneas in Response to Timolol Maleate Solutions Containing Various Preservatives
- Source :
- Alternatives to Laboratory Animals. 24:21-29
- Publication Year :
- 1996
- Publisher :
- SAGE Publications, 1996.
-
Abstract
- The effects of 0.125%, 0.25% and 0.5% timolol maleate on the opacity, thickness and hydration of isolated porcine corneas were determined. The effects of adding 0.005% benzalkonium chloride, 0.5% chlorbutanol or a combination of 0.026% methyl p-hydroxybenzoate, 0.014% propyl p-hydroxybenzoate and 0.2% chlorbutanol to the timolol solutions were also assessed. Over a 4-hour incubation period, a concentration-related opacity developed in the presence of timolol alone, and was not greatly affected by the addition of the p-hydroxybenzoate mixture. However, the addition of benzalkonium chloride or the higher concentration of chlorbutanol markedly increased opacity. Corneal thickness increased significantly in the presence of 0.25% and 0.5% timolol and even further in the presence of the preservatives, chlorbutanol being the most potent. Hydration increased slightly with time and also in the presence of each of the preservatives. The need to achieve a balance between possible corneal toxicity and effective batericidal activity is discussed.
- Subjects :
- medicine.medical_specialty
Preservative
genetic structures
Eye disease
Timolol
Toxicology
030226 pharmacology & pharmacy
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
Ophthalmology
Cornea
medicine
Increased thickness
Timolol maleate
business.industry
Corneal opacity
General Medicine
medicine.disease
eye diseases
Surgery
Medical Laboratory Technology
medicine.anatomical_structure
030220 oncology & carcinogenesis
Toxicity
sense organs
business
medicine.drug
Subjects
Details
- ISSN :
- 26323559 and 02611929
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Alternatives to Laboratory Animals
- Accession number :
- edsair.doi...........2fef7c7467c09e20add6e579fddf01aa
- Full Text :
- https://doi.org/10.1177/026119299602400105