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A single nucleotide polymorphism in CYP1B1 leads to differential prostate cancer risk and telomere length

Authors :
Dai Bo
Hua Xu
Gao Xiang Li
Yu Zhu
Cheng Yuan Gu
Yao Zhu
Dingwei Ye
Xiao Jian Qin
Source :
Journal of Cancer. 9:269-274
Publication Year :
2018
Publisher :
Ivyspring International Publisher, 2018.

Abstract

BACKGROUND: Cytochrome P450 1B1 (CYP1B1) is a key enzyme in its oestrogen metabolism pathway, giving rise to hydroxylation and conjugation. Functionally relevant genetic variants within CYP1B1 may affect the telomere length and subsequently lead to prostate carcinogenesis. METHODS: We evaluated 8 CYP1B1 tag single nucleotide polymorphisms (SNPs) in 1015 men with prostate cancer (PCa) and 1052 cancer-free controls, and calculated odds ratios (ORs) and 95% confidence intervals (CIs) to estimate their association with risk of PCa. The influence of CYP1B1 SNPs on the relative telomere lengths was then appraised in peripheral blood leukocytes using real-time PCR. RESULTS:CYP1B1 rs1056836 variant was associated with decreased risk of PCa [odds ratio (OR): 0.80; 95% confidence interval (CI): 0.68-0.99, P = 0.041]. Longer telomere length showed a significantly higher proportion of the CYP1B1 rs1056836 CG/GG genotypes, compared with that of the CC genotype (OR: 1.60, 95% CI: 1.04-2.45). CONCLUSION: Our findings suggest that genetic variants within CYP1B1 may confer genetic susceptibility to PCa by altering telomere length.

Details

ISSN :
18379664
Volume :
9
Database :
OpenAIRE
Journal :
Journal of Cancer
Accession number :
edsair.doi...........2fe03ec423a350dce49b1caf9393f294