Imaging in Drug Development: Animal Models, Handling and Physiological Constraints

In this chapter we delve into the primary components and operational issues that need to be considered in the setup and operation of a dedicated animal imaging facility with the use of PET, SPECT, CT, MR, and other platforms. The special conditions required for successful animal models, needs of the animals during imaging, and the avoidance of environmental and physiologic artifacts to the images are discussed.