Effect of daily ginger consumption on platelet aggregation

Objectives Ginger extracts gingerol and paradol exhibit anti-platelet aggregation properties. Prior studies have shown a reduction in platelet aggregation; however, results remain inconclusive due to heterogeneity of the used methods i.e. different dose regimen, ginger formulation, and study participants. The main aim of the study was to evaluate the effect of ginger consumption on platelet aggregation upon healthy participants. Methods Forty healthy male and female participants were randomized (1:1) to consume ginger tea four gram once daily vs. twice daily for five consecutive days. The primary outcome was inhibition in platelet aggregation which was assessed at baseline and at day five post ginger intake using agonists Adenosine Diphosphonate, Arachidonic Acid, Collagen, Ristocetin and Epinephrine. Results Complete blood count, platelet aggregation and platelets morphology at baseline were not statistically different between study groups. Taking ginger four gram once daily did not show an effect on the platelet aggregation using Adenosine Diphosphonate, Arachidonic Acid, Collagen and Ristocetin, except Epinephrine where reduction in platelet aggregation had been observed (p = 0.032). Dose increment to ginger 4 g twice daily does not influence the platelet aggregation using any of the agonists. Females have shown increase in platelet aggregation inhibition compared to males in response to Arachidonic Acid (p = 0.01). Conclusion Results showed that ginger 4 g daily had an impact on platelet aggregation using Epinephrine only, with no change observed after dose increment. Platelet aggregation inhibition was higher among females using Arachidonic Acid only.