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Metrological support for DNA sequencing
- Source :
- Measurement Techniques. 55:345-350
- Publication Year :
- 2012
- Publisher :
- Springer Science and Business Media LLC, 2012.
-
Abstract
- We discuss the operating principle of a pyrosequencer, which is an instrument for sequential reading of the nucleotide sequence of DNA molecules in pyrophosphate sequencing (pyrosequencing). We formulate the basic principles of metrological support for DNA sequencing and we present the results of studies of the metrological characteristics of the GS FLX pyrosequencer. We list the major problems encountered in designing a system for metrological support of DNA sequencing.
Details
- ISSN :
- 15738906 and 05431972
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Measurement Techniques
- Accession number :
- edsair.doi...........2fa039ad77379dbcb1a42dbabad4d621