Synthesis of carbon-14 labeled 4-[4-[2-[2-[bis(4-chlorophenyl) methoxy]ethyl sulfonyl][1-14C]ethoxy]phenyl]-1,1,1-trifluoro-2-butanone

Carbon-14 labeled 4-[4-[2-[2-[bis(4-chlorophenyl)methoxyethylsulfonyl] [1-14C]ethoxy]phenyl]-1,1,1-trifluoro-2-butanone was prepared in a six step radioactive synthesis from 2-bromo[1-14C]acetic acid. The overall radiochemical yield was 2.2%. The specific activity of the final product was found to be 42μCi/mg with a radiochemical purity of >98%. Copyright © 2002 John Wiley & Sons, Ltd.