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SIV envelope glycoprotein epitopes recognized by antibodies from infected or vaccinated rhesus macaques
- Source :
- Journal of Medical Primatology. 22:129-137
- Publication Year :
- 1993
- Publisher :
- Wiley, 1993.
-
Abstract
- We analyzed SIV-specific monkey sera to localize B-cell epitopes of the envelope glycoprotein of SIV (gp130), using overlapping synthetic peptides representing the entire SIV gp130 protein and sera from experimentally infected monkeys and monkeys immunized with whole, inactivated SIV. A B-cell epitope which induces neutralizing antibody production and T-cell responses was characterized as well as a new B-cell epitope and a previously described neutralizing epitopes. Vaccinated monkey sera recognize the three epitopes differentially relative to unimmunized controls, and a correlation appears to exist between degree of cross-neutralization by infected monkey sera and degree of binding to these three regions.
- Subjects :
- chemistry.chemical_classification
General Veterinary
animal diseases
Immunogenicity
Simian immunodeficiency virus
Biology
medicine.disease_cause
Virology
Epitope
Microbiology
chemistry
Viral envelope
Humoral immunity
medicine
biology.protein
Animal Science and Zoology
Antibody
Neutralizing antibody
Glycoprotein
Subjects
Details
- ISSN :
- 16000684 and 00472565
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Journal of Medical Primatology
- Accession number :
- edsair.doi...........2f866b9739ac30dfd6329354c1078dfd