Microfabrication Of Reproducible, Economical, Electroenzymatic Glucose Sensors

We present a method for fabricating electroenzymatic glucose sensors. The general approach i s to utilize thin- and thick-film deposition techniques similar to those used in the semiconductor processing industry. The sensors are fabricated in lots of 130, with the goal of a cheiving r eproducible s ensor performance and economical fabrication costs, using processes that can be readily up-scaled for manufacturing large numbers of sensors. The sensors are formed on a flexible substrate to provide less irritation and longer, more reliable operation when placed in vivo. Sensor operation has been characterized in vitro, and sensor performance has been found to meet