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Research Paper: Effects of Different Doses and Time-Dependency of Busulfan on Testes Parameters and Spermatogenesis in a Rat Model: A Quantitative Stereological Study
- Source :
- Journal of Advanced Medical Sciences and Applied Technologies. :155-162
- Publication Year :
- 2019
- Publisher :
- Negah Scientific Publisher, 2019.
-
Abstract
- Objectives: The current study aimed at evaluating testis parameters and spermatogenesis changes in male rats administrated by different busulfan doses and time to construct a subfertile animal model by stereological methods.Materials and Methods: In the present study, 150 male Wistar rats randomly divided into 5 groups. All experimental groups were treated by different concentrations of busulfan (0.0, 2.5, 5, 10, and 15 mg/kg). Rats were sacrificed 1, 15, and 30 days after busulfan treatment. The tissue processing was done for stereological study and the results were analyzed by the one-way ANOVA followed by the Duncan test. Results: The most stereological parameters such as testes weight and volume, tubules volume density, interstitial tissue (P
Details
- ISSN :
- 25384473 and 24235903
- Database :
- OpenAIRE
- Journal :
- Journal of Advanced Medical Sciences and Applied Technologies
- Accession number :
- edsair.doi...........2f66cad2bb92b80d2726b246fc0c250e