Telomerase Activity and p53 Protein Accumulation in Lugol-Stained and Lugol-Unstained Esophageal Squamous Epithelia

Esophageal squamous cell carcinoma (ESC) is one of the most common cancers worldwide [1]. Its prognosis remains poor despite recent advances in both diagnosis and therapy. Moreover, multiple primary ESC is not uncommon [2,3]. These reports support the concept that the entire esophagus may be considered as a single area of carcinogenesis. The elucidation of the carcinogenesis of ESC may have a considerable effect on early diagnosis and therapy.