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Circulating HtrA2 as a novel biomarker for mitochondrial induced cardiomyocyte apoptosis and ischemia-reperfusion injury in ST-segment elevation myocardial infarction
- Source :
- International Journal of Cardiology. 243:485-491
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Background Ischemia-reperfusion (I/R) injury in ST-segment elevation myocardial infarction (STEMI) significantly contributes to overall myocardial damage. As a consequence of I/R injury in the heart, the high-temperature requirement protein A2 (HtrA2) is released from the mitochondrial intermembrane space of cardiomyocytes to the cytoplasm, whereupon it induces apoptosis. Methods Serum was obtained from STEMI ( n =37), non–ST-segment elevation myocardial infarction (NSTEMI) ( n =20), stable coronary artery disease (CAD) ( n =17) and patients with CAD excluded ( n =9). In STEMI, I/R injury was assessed via measurement of ST-segment resolution. Results HtrA2 was significantly increased in STEMI compared to NSTEMI, stable CAD and patients with CAD excluded (981.3 (IQR: 543.5–1526.2)pg/mL vs. 494.5 (IQR: 413.8–607)pg/mL vs. 291 (IQR: 239–458.5)pg/mL vs. 692.2 (IQR: 276.6–964.7)pg/mL; p ≤0.0001). STEMI patients with HtrA2 level of at least the median or above had a higher peak creatine kinase (CK) ( p =0.0002) and cardiac troponin T levels (cTnT) ( p =0.0019). Significantly more STEMI patients with HtrA2 levels of at least the median or above were identified as I/R injury (87% vs. 42%; p Conclusion HtrA2 shows promise as a novel potential biomarker for mitochondrial-induced cardiomyocyte apoptosis and may help to identify I/R injury after STEMI.
- Subjects :
- medicine.medical_specialty
biology
business.industry
medicine.medical_treatment
Ischemia
Percutaneous coronary intervention
030204 cardiovascular system & hematology
medicine.disease
Coronary artery disease
03 medical and health sciences
0302 clinical medicine
Troponin complex
Internal medicine
biology.protein
Cardiology
Medicine
ST segment
Creatine kinase
cardiovascular diseases
030212 general & internal medicine
Myocardial infarction
Cardiology and Cardiovascular Medicine
business
Reperfusion injury
Subjects
Details
- ISSN :
- 01675273
- Volume :
- 243
- Database :
- OpenAIRE
- Journal :
- International Journal of Cardiology
- Accession number :
- edsair.doi...........2f0d4b94eaccb7d926c68c7e778f95e0