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ChemInform Abstract: Enols as Potent Antibacterial Agents
- Source :
- ChemInform. 33
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- This paper describes the discovery of α-trifluoroketoacetamides as potent antibacterial agents against Gram-positive organisms. The initial SAR indicates that the aryl ethyl side chain is essential in maintaining antibacterial activity. The SAR observations have been utilized to design a bioisostere for the α-trifluoroketoacetamide with good activity against Gram-positive organisms.
Details
- ISSN :
- 15222667 and 09317597
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- ChemInform
- Accession number :
- edsair.doi...........2e8db84b150ab598eb1f499d72fb1a73