Association between Vitamin D and Metabolic Indexes in Patients with Polycystic Ovary Syndrome

Objective: The aim of this study was to investigate the effect of vitamin D on the metabolic characteristics of polycystic ovary syndrome(PCOS) and its mechanism. Methods and Results: 155 cases of PCOS patients and 74 non-PCOS women withmatched age and BMI were enrolled in this study.Data were collected from May 2016 to November 2017. Plasma 25-hydroxyvitamin D[25(OH)D], metabolic markers, and sex hormones were measured. Homeostasis model assessment(HOMA-IR), triglyceride(TG), testosterone(T), free androgen index(FAI) and uric acid(UA) were significantly increased(P Conclusion: Serum level of vitamin D was lower in women with PCOS than controls. Vitamin D in overweight/obese women with PCOS was lower than normal-weight women with PCOS. Vitamin D is associated with insulin resistance and cardiovascular disease risk in overweight/obese women with PCOS. Disclosure S. Shanmei: None. L. Jiayi: None. L. Yikun: None. Q. Chengcheng: None. Y. Jiamiao: None. Y. Bi: None. D. Zhu: None.