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Primary tumor resection in colorectal cancer patients with unresectable distant metastases: a minireview

Primary tumor resection in colorectal cancer patients with unresectable distant metastases: a minireview

Authors :
Junge Bai
Ming Yang
Zheng Liu
Sergey Efetov
Cuneyt Kayaalp
Audrius Dulskas
Darcy Shaw
Xishan Wang
Source :
Frontiers in Oncology. 13
Publication Year :
2023
Publisher :
Frontiers Media SA, 2023.

Abstract

Colorectal cancer (CRC) is the second most common cause of cancer-related death among both men and women worldwide and the third most common cancer overall. About 20% of patients diagnosed with CRC were discovered to have distant metastatic lesions, the majority of which were located in the liver. For the optimum treatment of CRC patients with hepatic metastases, interventional radiologists, medical oncologists, and surgeons must all collaborate. The surgical excision of the primary tumor is an important part of CRC treatment since it has been found to be curative in cases of CRC with minimal metastases. However, given the evidence to date was gathered from retrospective data, there is still controversy over the effectiveness of primary tumor resection (PTR) in improving the median overall survival (OS) and quality of life. Patients who have hepatic metastases make up a very tiny fraction of those who are candidates for resection. With a focus on the PTR, this minireview attempted to review the current advancements in the treatment options for hepatic colorectal metastatic illness. This evaluation also included information on PTR’s risks when performed on individuals with stage IV CRC.

Subjects

Subjects :
Cancer Research
Oncology

Details

ISSN :
2234943X
Volume :
13
Database :
OpenAIRE
Journal :
Frontiers in Oncology
Accession number :
edsair.doi...........2d57f2da694567154f08c8195f1cdd53
Full Text :
https://doi.org/10.3389/fonc.2023.1138407