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Classics in Neuroimaging: Development of PET Tracers for Imaging Monoamine Oxidases
- Source :
- ACS Chemical Neuroscience. 10:1867-1871
- Publication Year :
- 2019
- Publisher :
- American Chemical Society (ACS), 2019.
-
Abstract
- In this Viewpoint, we highlight the history of positron emission tomography (PET) radiotracer development to quantify changes in monoamine oxidase (MAO)-A and -B enzyme expression or activity. MAO-A and MAO-B are critical for understanding monoaminergic pathways in psychiatric addiction disorders, and more recently in neurodegenerative disorders with MAO-B expression in astrogliosis. Unique radiochemical innovations have been shown for neuroimaging of MAOs including the clinical translation of irreversible propargylamine-based suicide inhibitors, application of deuterium-substitution to slow down metabolism, development of trapped metabolite imaging agents, and unique 11C-carbonylation chemistry toward novel high-affinity reversibly binding inhibitors.
- Subjects :
- 0303 health sciences
medicine.diagnostic_test
biology
Physiology
Chemistry
Monoamine oxidase
Cognitive Neuroscience
Cell Biology
General Medicine
medicine.disease
Biochemistry
Astrogliosis
03 medical and health sciences
0302 clinical medicine
Monoamine neurotransmitter
Neuroimaging
Positron emission tomography
Monoaminergic
medicine
biology.protein
Monoamine oxidase B
Monoamine oxidase A
Neuroscience
030217 neurology & neurosurgery
030304 developmental biology
Subjects
Details
- ISSN :
- 19487193
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- ACS Chemical Neuroscience
- Accession number :
- edsair.doi...........2d3f943e49518af477b271f50658fe26