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Expression of mucin 1 possessing a 3′-sulfated core1 in recurrent and metastatic breast cancer
- Source :
- International Journal of Cancer. 137:1652-1660
- Publication Year :
- 2015
- Publisher :
- Wiley, 2015.
-
Abstract
- Breast cancer is the most frequent cancer threatening the lives of women between the ages of 30 and 64. The cancer antigen 15-3 assay (CA15-3) has been widely used for the detection of breast cancer recurrence; however, its sensitivity and specificity are inadequate. We previously found that the breast cancer cell line YMBS secretes mucin 1 possessing 3′-sulfated core1 (3Score1-MUC1) into the medium. Therefore, we here evaluated whether 3Score1-MUC1 is secreted into the blood streams of breast cancer patients, and whether it can serve as an improved breast cancer marker. We developed a lectin-sandwich immunoassay, called Gal4/MUC1, using a 3′-sulfated core1-specific galectin-4 and a MUC1 monoclonal antibody. Using the Gal4/MUC1 assay method, we found that 3Score1-MUC1 was profoundly expressed in the blood streams of patients with recurrent and/or metastatic breast cancer. The positive ratio of the Gal4/MUC1 assay was higher than that of the CA15-3 assay in both primary (n = 240) and relapsed (n = 43) patients, especially in the latter of which the positive ratio of Gal4/MUC1 was 86%. whereas that of CA15-3 was 47%. Furthermore, serum Gal4/MUC1 levels could more sensitively reflect the recurrence of primary breast cancer patients after surgery. Therefore, the Gal4/MUC1 assay should be an excellent alternative to the CA15-3 tumor marker for tracking the recurrence and metastasis of breast cancer.
- Subjects :
- Oncology
CA15-3
Cancer Research
medicine.medical_specialty
business.industry
Cancer
CA 15-3
medicine.disease
digestive system
Metastatic breast cancer
biological factors
digestive system diseases
Metastasis
Breast cancer
Internal medicine
medicine
CA19-9
skin and connective tissue diseases
business
neoplasms
Tumor marker
Subjects
Details
- ISSN :
- 00207136
- Volume :
- 137
- Database :
- OpenAIRE
- Journal :
- International Journal of Cancer
- Accession number :
- edsair.doi...........2cfc858740c332016f3f8c79e06eed96