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Multifunctional Biocompatible Fluorescent Carboxymethyl Cellulose Nanoparticles

Authors :
Sreejith Raveendran
Yasuhiko Yoshida
D. Sakthikumar
Takahiro Fukuda
Dhandayudhapani Brahatheeswaran
Balasubramanian Sivakumar
Toru Maekawa
Tomofumi Ukai
Ravindran Girija Aswathy
Source :
Journal of Biomaterials and Nanobiotechnology. :254-261
Publication Year :
2012
Publisher :
Scientific Research Publishing, Inc., 2012.

Abstract

A multifunctional nanoparticle based on carboxymethyl cellulose was developed. Folate group was attached to nanoparticle for specific recognition of cancerous cells and 5FU was encapsulated for delivering cytotoxicity. The whole system was able to track by the semiconductor quantum dots that were attached to the nanoparticle. The multifunctional nanoparticle was characterized by UV-VIS spectra, PL spectra, FTIR, TEM, SEM etc and was targeted to human breast cancer cell, MCF7. The biocompatibility of nanoparticle without drug and cytotoxicity rendered by nanoparticle with drug was studied with MCF7 and L929 cell lines. The epifluorescent images suggest that the folate-conjugated nanoparticles were more internalized by folate receptor positive cell line, MCF7 than the noncancerous L929 cells.

Details

ISSN :
21587043 and 21587027
Database :
OpenAIRE
Journal :
Journal of Biomaterials and Nanobiotechnology
Accession number :
edsair.doi...........2cdd4c6425f2baa3ec25735a7e44e92f