Back to Search
Start Over
ChemInform Abstract: Reactions of β-Bromo-N-heteroaromatics with Phenylacetonitrile
- Source :
- ChemInform. 22
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- The reaction of 3-bromopyridine with phenylacetonitrile in the presence of NaH in THF gave a simple substitution product, α-phenyl-3-pyridineacetonitrile, whereas the reaction of 5-bromopyrimidine with phenylacetonitrile under similar conditions gave a ring-transformation product, 2-amino-5-bromo-3-phenylpyridine. 3-bromoquinoline and 4-bromoisoquinoline underwent the former type reaction, while 3-bromo- and 3-chloroisoquinolines were converted into 2-amino-3-phenyl-1-naphthalencarbonitrile according to the latter type reaction
Details
- ISSN :
- 09317597
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- ChemInform
- Accession number :
- edsair.doi...........2ca0ac7225917a9926d4033b2544e832