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State-of-the-Art Glycomics Technologies in Glycobiotechnology
- Source :
- Advances in Glycobiotechnology ISBN: 9783030695897
- Publication Year :
- 2020
- Publisher :
- Springer International Publishing, 2020.
-
Abstract
- Glycosylation affects the properties of biologics; thus regulatory bodies classified it as critical quality attribute and force biopharma industry to capture and control it throughout all phases, from RD we will then highlight two emerging technologies based on porous graphitized carbon liquid chromatography and on ion-mobility mass spectrometry as both are highly promising tools to deliver an additional level of information for in-depth glycan analysis; additionally we elaborate on the advantages and challenges of different glycoanalytical technologies and their complementarity; finally, we briefly review applications thereof to biopharmaceutical products. This chapter provides an overview of current state-of-the-art analytical approaches for glycan characterization of biopharmaceuticals that can be employed to capture glycoprotein heterogeneity in a biopharmaceutical context.
Details
- ISBN :
- 978-3-030-69589-7
- ISBNs :
- 9783030695897
- Database :
- OpenAIRE
- Journal :
- Advances in Glycobiotechnology ISBN: 9783030695897
- Accession number :
- edsair.doi...........2c6a97debc8741679e76e031067a5aef