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Studies on Steroids. II. The Preparation and Properties of 17β-(N-Substituted 2-Amino-4-thiazolyl) androst-4-en-3β, 17α-diol Series and its Hydrogen Succinate
- Source :
- Chemical and Pharmaceutical Bulletin. 11:613-618
- Publication Year :
- 1963
- Publisher :
- Pharmaceutical Society of Japan, 1963.
-
Abstract
- 17β-(2-alkylamino-(or 2-arylamino-or 2-N, N-alkylarylamino-) thiazolyl) androst-4-en-3β, 17α-diol was prepared from corresponding 3-one with sodium boronhydride in dioxan or dioxane-methanol (1 : 1). 17β-(2-alkylamino-(or 2-arylamino-)-4-thiazolyl) androst-4-en-3β, 17α-diol 3-(hydrogen succinate) and O, N-bis(hydrogen succinate) were obtained from corresponding 3β, 17α-diol and 17α-ol-3-one with succinic anhydride. Some of this substance had a digitalis like properties.
Details
- ISSN :
- 13475223 and 00092363
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Chemical and Pharmaceutical Bulletin
- Accession number :
- edsair.doi...........2bf33c03d5e88fa34ebd935577025f44