Back to Search
Start Over
Clinical and Pathologic Features of Spontaneous Klebsiella pneumoniae Infection in 9 Rhesus Macaques (Macaca mulatta)
- Source :
- Comparative Medicine. 70:183-189
- Publication Year :
- 2020
- Publisher :
- American Association for Laboratory Animal Science, 2020.
-
Abstract
- Klebsiella pneumoniae is a gram-negative bacterium found in the environment and as a commensal in humans and animals. In humans, K. pneumoniae is one of the most serious nosocomial infections encountered currently and is characterized by liver abscesses, pneumonia, and bacteremia resulting in meningoencephalitis and endophthalmitis. K. pneumoniae in veterinary medicine is rarely reported in NHP, and recent literature describing this disease is sparse. In our colony of predominantly outdoor-housed rhesus macaques (Macaca mulatta), K. pneumoniae is cultured infrequently from healthy animals during routine screening and is even rarer in sick animals. This report summarizes the clinical and postmortem findings associated with this pathogen in 9 rhesus macaques and compares these results with the disease outcomes reported for humans. In these cases, K. pneumoniae infection was confirmed through culture or PCR testing or both. In our experience, when this bacterium does cause clinical signs, the disease is rapidly progressive and severe. At necropsy of NHP, the findings are strikingly similar to opportunistic Klebsiella-associated syndromes described in humans and include liver abscesses, meningoencephalitis, and endophthalmitis. In addition, many of the affected macaques had similar risk factors to humans that succumb to disease, thus perhaps indicating that rhesus macaques could be a viable model for investigating these syndromes.
- Subjects :
- Routine screening
General Veterinary
biology
040301 veterinary sciences
Klebsiella pneumoniae
business.industry
Meningoencephalitis
04 agricultural and veterinary sciences
Disease
medicine.disease
biology.organism_classification
General Biochemistry, Genetics and Molecular Biology
0403 veterinary science
Endophthalmitis
Bacteremia
Immunology
medicine
business
Pathogen
Pneumonia (non-human)
Subjects
Details
- ISSN :
- 15320820
- Volume :
- 70
- Database :
- OpenAIRE
- Journal :
- Comparative Medicine
- Accession number :
- edsair.doi...........2b9ba6fea1b7cb3c4005e84efadcf82c